This study evaluated associations between general (negative affectivity) and specific (anxiety sensitivity) factors that may relate to the mindfulness skill domains assessed by the Kentucky Inventory of Mindfulness Skills. Participants were 154 young adults (88 females; M(age) = 22.4 years, SD = 7.9) recruited from the community. Partially consistent with predictions, higher levels of negative affectivity were significantly associated with lower levels of Awareness, Acceptance, and Describe mindfulness skills, and higher levels of anxiety sensitivity were significantly associated with lower levels of Awareness and Acceptance mindfulness skills. Additionally, negative affectivity and anxiety sensitivity each demonstrated unique relations to participants' ability to experience the present state without evaluating or judging its content (Accept factor), after accounting for their shared variance, but only anxiety sensitivity demonstrated a unique association to the Act with Awareness factor independent of variance explained by negative affectivity. Findings are discussed in relation to theory and research on mindfulness processes.